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Bextra (valdecoxib) is
in a class of drugs called nonsteroidal
anti-inflammatory drugs (NSAIDs). Valdecoxib
works by reducing substances in the body that
cause inflammation, pain, and fever, and is used
to reduce pain, inflammation, and stiffness
caused by osteoarthritis and adult rheumatoid
arthritis.
Bextra’s label already warns against serious
skin reactions as a possible side effect, and
some trials found an increased risk of
unspecified “cardiovascular events” in Bextra
patients who had cardiac bypass surgery.
Prescription nonsteroidal anti-inflammatory
drugs (NSAIDs), such as Bextra (valdecoxib) are
one of the leading classes of drugs that cause
Stevens Johnson Syndrome (SJS), toxic epidermal
necrolysis (TEN), and erythema multiforme (EM)
due to drug allergy reactions. Bextra has also
been linked to possible cardiac problems
including heart attacks and strokes.
In October 2004, Pfizer announced that two
clinical trials showed heart bypass surgery
patients taking Bextra increased their risk of
stroke and heart attack. The news came just
weeks after the FDA withdrew Vioxx, a similar
COX-2 inhibitor, from the market due to an
increased risk of cardiovascular events.
Possible Bextra Side Effects
-
Application site disorders: Cellulitis,
dermatitis contact
-
Cardiovascular: Aggravated hypertension,
aneurysm, anginapectoris, arrhythmia,
cardiomyopathy, congestive heart failure,
coronary artery disorder, heart murmur,
hypotension
- Central,
peripheral nervous system: Cerebrovascular
disorder, hypertonia, hypoesthesia,
migraine, neuralgia, neuropathy, pares-thesia,
tremor, twitching, vertigo
- Endocrine:
Goiter
- Female
reproductive:
Amenorrhea, dysmenorrhea, leukorrhea,
mastitis, menstrual disorder, menorrhagia,
menstrual bloating, vagi-nal hemorrhage
-
Gastrointestinal: Abnormal stools,
constipation, diverticulosis, dry mouth,
duodenal ulcer, duodenitis, eructation,
esophagitis, fecal incontinence, gastric
ulcer, gastritis, gastroenteritis,
gastroe-sophageal reflux, hematemesis,
hematochezia, hemorrhoids, hem-orrhoids
bleeding, hiatal hernia, melena, stomatitis,
stool frequency increased, tenesmus, tooth
disorder, vomiting
- General:
Allergy aggravated, allergic reaction,
asthenia, chest pain, chills, cyst NOS,
edema generalized, face
edema, fatigue, fever, hot flushes,
halitosis, malaise, pain, periorbital
swelling, peripheral pain Hearing and
vestibular: Ear abnormality, earache,
tinnitus
- Heart rate
and rhythm: Bradycardia, palpitation,
tachycardia
- Hemic:
Anemia
- Liver and
biliary system: Hepatic function abnormal,
hepatitis, ALT increased, AST increased
- Male
reproductive:
Impotence, prostatic disorder
- Metabolic
and nutritional: Alkaline phosphatase
increased, BUN increased, CPK increased,
creatinine increased, diabetes mellitus,
glycosuria, gout, hypercholesterolemia,
hyperglycemia, hyperkalemia, hyperlipemia,
hyperuricemia, hypocalcemia, hypokalemia,
LDH increased, thirst increased, weight
decrease, weight increase, xerophthalmia
-
Musculoskeletal: Arthralgia, fracture
accidental, neck stiffness, osteoporosis,
synovitis, tendonitis
- Neoplasm:
Breast neoplasm, lipoma, malignant ovarian
cyst
- Platelets
(bleeding or clotting): Ecchymosis,
epistaxis, hematoma NOS, thrombocytopenia
-
Psychiatric: Anorexia,
anxiety, appetite increased, confusion,
depression,
depression aggravated, insomnia,
nervousness, morbid dreaming, somnolence
- Resistance
mechanism disorders: Herpes simplex, herpes
zoster, infection fungal,infection soft
tissue, infection viral, moniliasis,
moniliasis genital, otitis media
-
Respiratory: Abnormal breath sounds,
bronchitis, bronchospasm, coughing, dyspnea,
emphysema, laryngitis, pneumonia,
pharyngitis, pleurisy, rhinitis
- Skin and
appendages:
Acne, alopecia, dermatitis, dermatitis
fun-gal, eczema, photosensitivity allergic
reaction, pruritus, rash ery-thematous, rash
maculopapular, rash psoriaform, skin dry,
skin hypertrophy, skin ulceration, sweating
increased, urticaria
- Special
senses: Taste perversion
- Urinary
system: Albuminuria, cystitis, dysuria,
hematuria, micturition frequency increased,
pyuria, urinary incontinence, urinary tract
infection
- Vascular:
Claudication intermittent, hemangioma
acquired, varicose vein
- Vision:
Blurred vision, cataract, conjunctival
hemorrhage, con-junctivitis, eye pain,
keratitis, vision abnormal
- White cell
and RES disorders: Eosinophilia, leukopenia,
leukocytosis, lymphadenopathy, lymphangitis,
lymphopenia
There may be
additional undocumented Bextra side effects.
If you are
experiencing any of the above listed side
effects, and have taken Bextra, contact
Belluck & Fox immediately for a
free legal evaluation.
Drug litigation can be extremely complex. It is
best to seek the counsel of a personal injury
attorney with experience in this field of law.
Belluck & Fox has substantial experience with
defective product litigation, including
pharmaceutical and medical product cases. We
will provide you with personalized, professional
legal representation.
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Belluck & Fox, LLP
295 Madison Avenue, 37th Floor
New York, New York, 10017
Phone: 212-681-1575
Toll Free: 1-877-NYLAW08
Fax: 212-681-1574
Email:
bfinfo@belluckfox.com |
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Belluck & Fox, L.L.P., Attorneys At Law, New York NY Lawyers. All
Rights Reserved.
Handling Pharmaceutical Negligence Cases including
Bextra,
Vioxx,
Crestor,
Celebrex
Bextra Lawyers representing victims of dangerous arthritis drug,
valdecoxib, prescription, malpractice,
negligence, and consumer injuries including heart attacks,
strokes, Stevens Johnson Syndrome.
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